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Discuss the achievements and challenges associated with NGS.These applications further enrich cancer research and drive future breakthroughs.ĭuring this webinar, our expert speakers will: However, it’s also now possible to embrace the inherent heterogeneity of a tissue by performing single-cell sequencing and understanding individual cells (but without spatial context). If someone is seeking to characterize average state of many cells, bulk sequencing is still a fantastic, straightforward application. Furthermore, cellular characterization can occur at multiple levels of resolution. It can now be used to characterize the proteome, epigenome, noncoding RNAs, and even small RNAs. Additionally, the occurrence of shared targetable alterations across diverse tumor types has prompted new paradigms in the application of genomic profiling and the design of clinical trials.Īlthough often perceived as a primarily genomic and/or transcriptomic analysis approach, NGS has evolved beyond the genome and transcriptome. Genomic assays that enable characterization of somatic and germline defects in individual tumor samples are increasingly being used in clinical diagnostics as a means of identifying therapeutic options. Emerging clinical applications of cancer genomics include monitoring treatment responses and characterizing mechanisms of resistance.
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In addition to identifying individual targetable alterations, sequencing methods can now reveal tumor mutational load and tumor-specific antigens that might predict a therapeutic response to targeted therapies, immune-checkpoint inhibitors, and personalized anticancer vaccines. The importance of building firm foundations in robust and reproducible research technologies, democratization of automated workflows, and digital connectivity of data.Ĭancer research using next-generation sequencing (NGS) has ushered in numerous advancements in diagnosis and treatment.The challenges of translating new techniques-such as liquid biopsies-into regulated, scalable methodologies that will drive future global diagnostics and therapeutics.The urgent need for translational research of biomarkers that have clinical relevance for optimizing diagnosis and treatment plans.The latest developments in integrated diagnostics and patient profiling, combining molecular and proteomics workflows.
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The considerable knowledge built up over years-and especially during the recent COVID-19 pandemic-is relevant to many disease states and can be applied universally, ensuring that globally standardized, scalable technologies can realize their full clinical potential. This webinar takes a closer look at this need, particularly in the oncology space, and discusses what the future for workflow validation might be. The translation of bench research into the clinical environment has accelerated significantly in recent years, and the need for clinically validated workflows has never been stronger. This webinar will last for approximately 60 minutes.